Structure of PDB 5kn3 Chain A Binding Site BS01

Receptor Information
>5kn3 Chain A (length=347) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLDFPEYDGVDRVVNVNAKNYKNVFKKYEVLALLYHEPPEDDKASQRQFE
MDELILELAAQVLEDKGVGFGMVDSEKDAAVAKKLGLTEEDSVYVFKGDE
VIEYDGEFSADTLVEFLLDVLEDPVELIEGERELQAFENIEDDNKLIGYF
KNKDSEHYKAYEDAAEEFHPYIPFFATFDSKVAKKLTLKLNEIDFYEAFM
EEPVTIPDKPNSEEEIVSFVEAHKRSTLRKLKPESMYETWEDDLDGIHIV
AFAEETDPDGYEFLETLKAVAQDNTDNPDLSIIWIDPDDFPLLVPYWEKT
FNIDLSAPQIGVVNVTDADSVWMEMDDEEDLPSAEELEDWLEDVLEG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5kn3 Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5kn3 Characterization of Post-Translational Modifications to Calsequestrins of Cardiac and Skeletal Muscle.
Resolution1.849 Å
Binding residue
(original residue number in PDB)		N17 V18 M74 V75 D80
Binding residue
(residue number reindexed from 1)		N15 V16 M72 V73 D78
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0007029 endoplasmic reticulum organization
GO:0009408 response to heat
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
GO:0045214 sarcomere organization
GO:0051258 protein polymerization
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:1901341 positive regulation of store-operated calcium channel activity
GO:2001256 regulation of store-operated calcium entry
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0030018 Z disc
GO:0033017 sarcoplasmic reticulum membrane
GO:0033018 sarcoplasmic reticulum lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5kn3, PDBe:5kn3, PDBj:5kn3
PDBsum5kn3
PubMed27649144
UniProtQ05JF3

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