Structure of PDB 5kla Chain A Binding Site BS01

Receptor Information
>5kla Chain A (length=337) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGRSRLLEDFRNQRYPNLQLRDLANHIVEFSQDQHGSRFIQQKLERATAA
EKQMVFSEILAAAYSLMTDVFGNYVIQKFFEFGTPEQKNTLGMQVKGHVL
QLALQMYGCRVIQKALESISPEQQQEIVHELDGHVLKCVKDQNGNHVVQK
CIECVDPVALQFIINAFKGQVYSLSTHPYGCRVIQRILEHCTAEQTTPIL
DELHEHTEQLIQDQYGNYVIQHVLEHGKQEDKSILINSVRGKVLVLSQHK
FASNVVEKCVTHATRGERTGLIDEVCTFNDNALHVMMKDQYANYVVQKMI
DVSEPTQLKKLMTKIRPHMAALRKYTYGKHINAKLEK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5kla Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio.
Resolution1.14 Å
Binding residue
(original residue number in PDB)		Q1123 R1127 Q1130 F1160 N1162 Y1163 Y1196 R1199 Q1202 H1235 C1270 R1271 Q1274 Y1304 N1306 Y1307 Q1310 K1339 S1342 N1343 E1346 N1382 Y1383 Q1386 Y1416 H1419
Binding residue
(residue number reindexed from 1)		Q34 R38 Q41 F71 N73 Y74 Y107 R110 Q113 H146 C181 R182 Q185 Y215 N217 Y218 Q221 K250 S253 N254 E257 N293 Y294 Q297 Y327 H330
Binding affinityPDBbind-CN: Kd=26.3nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:5kla, PDBe:5kla, PDBj:5kla
PDBsum5kla
PubMed27482653
UniProtP25822|PUM_DROME Maternal protein pumilio (Gene Name=pum)

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