Structure of PDB 5kl8 Chain A Binding Site BS01

Receptor Information
>5kl8 Chain A (length=309) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RSRLLEDFRNQQDQHGSRFIQQKLERATAAEKQMVFSEILAAAYSLMTDV
FGNYVIQKFFEFGTPEQKNTLGMQVKGHVLQLALQMYGCRVIQKALESIS
PEQQQEIVHELDGHVLKCVKDQNGNHVVQKCIECVDPVALQFIINAFKGQ
VYSLSTHPYGCRVIQRILEHCTAEQTTPILDELHEHTEQLIQDQYGNYVI
QHVLEHGKQEDKSILINSVRGKVLVLSQHKFASNVVEKCVTHATRGERTG
LIDEVCTFNDNALHVMMKDQYANYVVQKMIDVSEPTQLKKLMTKIRPHMA
ALRKYTYGK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5kl8 Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		N1162 Y1163 M1195 Y1196 R1199 Q1231 H1235 Y1268 R1271 Q1274 N1306 Y1307 Q1310 S1342 N1343 E1346 N1382 Y1383 Q1386 K1413 Y1414 T1415 Y1416
Binding residue
(residue number reindexed from 1)		N53 Y54 M86 Y87 R90 Q122 H126 Y159 R162 Q165 N197 Y198 Q201 S233 N234 E237 N273 Y274 Q277 K304 Y305 T306 Y307
Binding affinityPDBbind-CN: Kd=12nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:5kl8, PDBe:5kl8, PDBj:5kl8
PDBsum5kl8
PubMed27482653
UniProtP25822|PUM_DROME Maternal protein pumilio (Gene Name=pum)

[Back to BioLiP]