Structure of PDB 5kcw Chain A Binding Site BS01
Receptor Information
>5kcw Chain A (length=233) Species:
9606
(Homo sapiens) [
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NSLALSLTADQMVSALLDAEPPILYSEYTRPFSEASMMGLLTNLADRELV
HMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFA
PNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLN
SGVYTFKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIR
HMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
Ligand information
>5kcw Chain C (length=10) Species:
9606
(Homo sapiens) [
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HKILHRLLQD
Receptor-Ligand Complex Structure
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PDB
5kcw
Full antagonism of the estrogen receptor without a prototypical ligand side chain.
Resolution
1.905 Å
Binding residue
(original residue number in PDB)
I358 K362 V376 E380 D538 L539 E542
Binding residue
(residue number reindexed from 1)
I53 K57 V71 E75 D223 L224 E227
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:5kcw
,
PDBe:5kcw
,
PDBj:5kcw
PDBsum
5kcw
PubMed
27870835
UniProt
P03372
|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)
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