Structure of PDB 5kct Chain A Binding Site BS01
Receptor Information
>5kct Chain A (length=236) Species:
9606
(Homo sapiens) [
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KNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADR
ELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKL
LFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSII
LLNSGVYTFKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILS
HIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
Ligand information
>5kct Chain C (length=10) Species:
9606
(Homo sapiens) [
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HKILHRLLQD
Receptor-Ligand Complex Structure
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PDB
5kct
Full antagonism of the estrogen receptor without a prototypical ligand side chain.
Resolution
1.6 Å
Binding residue
(original residue number in PDB)
I358 K362 L372 H373 Q375 V376 E380 D538 L539 E542
Binding residue
(residue number reindexed from 1)
I56 K60 L70 H71 Q73 V74 E78 D226 L227 E230
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:5kct
,
PDBe:5kct
,
PDBj:5kct
PDBsum
5kct
PubMed
27870835
UniProt
P03372
|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)
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