Structure of PDB 5kcf Chain A Binding Site BS01
Receptor Information
>5kcf Chain A (length=236) Species:
9606
(Homo sapiens) [
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KNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADR
ELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKL
LFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSII
LLNSGVYTKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSH
IRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRL
Ligand information
>5kcf Chain D (length=10) Species:
9606
(Homo sapiens) [
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HKILHRLLQD
Receptor-Ligand Complex Structure
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PDB
5kcf
Full antagonism of the estrogen receptor without a prototypical ligand side chain.
Resolution
2.07 Å
Binding residue
(original residue number in PDB)
I358 K362 L372 H373 Q375 V376 E380 D538 L539 E542
Binding residue
(residue number reindexed from 1)
I56 K60 L70 H71 Q73 V74 E78 D225 L226 E229
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:5kcf
,
PDBe:5kcf
,
PDBj:5kcf
PDBsum
5kcf
PubMed
27870835
UniProt
P03372
|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)
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