Structure of PDB 5k9s Chain A Binding Site BS01

Receptor Information
>5k9s Chain A (length=425) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPK
FVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLAS
PHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLAC
GYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCW
AISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTG
TDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQV
VNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIE
PLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKI
EALQRHENESVYKASLNLIEKYFSV
Ligand information
Receptor-Ligand Complex Structure
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PDB5k9s Importin-alpha in complex with HNF1-beta peptide
Resolution2.4 Å
Binding residue
(original residue number in PDB)		R101 S105 W142 N146 S149 G150 T155 Q181 W184 N188 G191 D192 W231 R238 W273
Binding residue
(residue number reindexed from 1)		R28 S32 W69 N73 S76 G77 T82 Q108 W111 N115 G118 D119 W158 R165 W200
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5k9s, PDBe:5k9s, PDBj:5k9s
PDBsum5k9s
PubMed
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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