Structure of PDB 5k66 Chain A Binding Site BS01
Receptor Information
>5k66 Chain A (length=430) Species:
889517
(Saccharomyces cerevisiae CEN.PK113-7D) [
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TKLLVSLKVLVIQLNPQIGQVDQTIKRTWSILDKVTKSATYVKPDIILFP
EFALTGYSFHARKDILPYVTKKDEGPSFELAKSISEKFQCYTIIGYPEED
DEQKLYNSALVVNPQGGQIFNYRKTFLYDTEMNWDCEENPEGFQTFPMDF
SKCAKLSNEDSYNRDVTLKASIGISMDLSPYKFMAPFNHFEFSSFCVDNN
VELILCPMAWLNSTSITDKQTLHNNSLLEAAKNKIAFALKEQGLPLAGSQ
GIYQLKIGDSQRTPRVPSDDSTSEYKDMDEPDMSNVNYWILRFFPFLYFK
LRINWFKNSSLIESILGKTRMPLDHEYYKKHKDLLDSEEVIKDTVLEKTF
LGTSLGQPWKFQGKNAILVLANRCGTEDGTTIFAGSSGIYKFNGKKSSLD
SLNESVELLGNLGKGLEGAILREVQFEVFR
Ligand information
Ligand ID
ASN
InChI
InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1
InChIKey
DCXYFEDJOCDNAF-REOHCLBHSA-N
SMILES
Software
SMILES
CACTVS 3.370
N[C@@H](CC(N)=O)C(O)=O
ACDLabs 12.01
O=C(N)CC(N)C(=O)O
CACTVS 3.370
N[CH](CC(N)=O)C(O)=O
OpenEye OEToolkits 1.7.2
C(C(C(=O)O)N)C(=O)N
OpenEye OEToolkits 1.7.2
C([C@@H](C(=O)O)N)C(=O)N
Formula
C4 H8 N2 O3
Name
ASPARAGINE
ChEMBL
CHEMBL58832
DrugBank
DB00174
ZINC
ZINC000001532556
PDB chain
5k66 Chain A Residue 501 [
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Receptor-Ligand Complex Structure
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PDB
5k66
Structural basis for dual specificity of yeast N-terminal amidase in the N-end rule pathway.
Resolution
2.002 Å
Binding residue
(original residue number in PDB)
Y69 K136 Y140 S187 M188 A221 W222 L223
Binding residue
(residue number reindexed from 1)
Y57 K124 Y128 S175 M176 A209 W210 L211
Annotation score
1
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0008418
protein-N-terminal asparagine amidohydrolase activity
GO:0070773
protein-N-terminal glutamine amidohydrolase activity
Biological Process
GO:0030163
protein catabolic process
View graph for
Molecular Function
View graph for
Biological Process
External links
PDB
RCSB:5k66
,
PDBe:5k66
,
PDBj:5k66
PDBsum
5k66
PubMed
27791147
UniProt
N1P8Q8
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