Structure of PDB 5k1b Chain A Binding Site BS01

Receptor Information
>5k1b Chain A (length=264) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQESLLTCLADLFHSIAT
QVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEEPTWVH
EIFQGTLTNETRCLTCETISSKDEDFLDLSVDVSITHCLRGFSNTETLCS
EYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFSYRVVFPLELRLFPD
RMYDLVAVVVHCGSGPNRGHYIAIVKSHWLLFDDDIVEKIDAQAIEEFYK
NSESGYILFYQSRD
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5k1b Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5k1b Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		C186 C233 C236
Binding residue
(residue number reindexed from 1)		C113 C156 C159
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) G40 G45 H317 D332
Catalytic site (residue number reindexed from 1) G1 G6 H220 D233
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0004843 cysteine-type deubiquitinase activity
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
GO:0046872 metal ion binding
GO:0101005 deubiquitinase activity
Biological Process
GO:0006508 proteolysis
GO:0016579 protein deubiquitination
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5k1b, PDBe:5k1b, PDBj:5k1b
PDBsum5k1b
PubMed27373336
UniProtO75317|UBP12_HUMAN Ubiquitin carboxyl-terminal hydrolase 12 (Gene Name=USP12)

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