Structure of PDB 5k08 Chain A Binding Site BS01

Receptor Information
>5k08 Chain A (length=142) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CLAEGTRIFDPVTGTTHRIEDVVDGRKPIHVVAAAKDGTLHARPVVSWFD
QGTRDVIGLRIAGGAILWATPDHKVLTEYGWRAAGELRKGDRVAVRDVET
GELRYSVIREVLPTRRARTFDLEVEELHTLVAEGVVVHACSP
Ligand information
Ligand IDZPT
InChIInChI=1S/C2H4.3ClH.Pt/c1-2;;;;/h1-2H2;3*1H;/q;;;;+2/p-3
InChIKeyLJEKXYSRMGLQBW-UHFFFAOYSA-K
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6[CH2]1=[CH2][Pt+2]1([Cl-])([Cl-])[Cl-]
CACTVS 3.385[Cl-]|[Pt++]|1(|[Cl-])(|[Cl-])|C=C|1
FormulaC2 H4 Cl3 Pt
NameTrichloro(ethene)platinate(II);
Zeise's salt
ChEMBL
DrugBank
ZINC
PDB chain5k08 Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5k08 Structural insights into protein splicing inhibition by platinum therapeutics as potential anti-microbials
Resolution1.401 Å
Binding residue
(original residue number in PDB)		H439 C441
Binding residue
(residue number reindexed from 1)		H138 C140
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Biological Process
GO:0016539 intein-mediated protein splicing

View graph for
Biological Process
External links
PDB RCSB:5k08, PDBe:5k08, PDBj:5k08
PDBsum5k08
PubMed
UniProtP9WHJ3|RECA_MYCTU Protein RecA (Gene Name=recA)

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