Structure of PDB 5jzj Chain A Binding Site BS01

Receptor Information

>5jzj Chain A (length=271) Species: 9606 (Homo sapiens)

EVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKK
SKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDL
FDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQ
DGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAA
GVITYILLCGFPPFRGSEVLFDQILMGQVDFPSPYWDNVSDSAKELITMM
LLVDVDQRFSAVQVLEHPWVN

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5jzj Chain A Residue 701

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5jzj Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1.
• Resolution: 1.71 Å
• Binding residue (original residue number in PDB): N516 D533
• Binding residue (residue number reindexed from 1): N143 D160
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D511 K513 E515 N516 D533 T550
• Catalytic site (residue number reindexed from 1): D138 K140 E142 N143 D160 T177
• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:5jzj, PDBe:5jzj, PDBj:5jzj
• PDBsum: 5jzj
• PubMed: 27545623
• UniProt: O15075|DCLK1_HUMAN Serine/threonine-protein kinase DCLK1 (Gene Name=DCLK1)