Structure of PDB 5jxy Chain A Binding Site BS01

Receptor Information
>5jxy Chain A (length=196) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FNGVSEAELLTKTLPDILTFNLDIVIIGINPGLMAAYKGHHYPGPGNHFW
KCLFMSGLSEVQLNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFRE
GGRILVQKLQKYQPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIP
DTETLCYVMPSSSARCAQFPRAQDKVHYYIKLKDLRDQLKGIERNM
Ligand information
Receptor-Ligand Complex Structure
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PDB5jxy Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues.
Resolution1.71 Å
Binding residue
(original residue number in PDB)		P155 K246 A274 R275 A277 P280 R281
Binding residue
(residue number reindexed from 1)		P45 K136 A164 R165 A167 P170 R171
Enzymatic activity
Catalytic site (original residue number in PDB) N140 H151
Catalytic site (residue number reindexed from 1) N30 H41
Enzyme Commision number 3.2.2.29: thymine-DNA glycosylase.
Gene Ontology
Molecular Function
GO:0000700 mismatch base pair DNA N-glycosylase activity
Biological Process
GO:0006285 base-excision repair, AP site formation

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Molecular Function
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Biological Process
External links
PDB RCSB:5jxy, PDBe:5jxy, PDBj:5jxy
PDBsum5jxy
PubMed27580719
UniProtQ13569|TDG_HUMAN G/T mismatch-specific thymine DNA glycosylase (Gene Name=TDG)

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