Structure of PDB 5jxs Chain A Binding Site BS01

Receptor Information

>5jxs Chain A (length=476) Species: 12110 (Foot-and-mouth disease virus)

GLIVDTRDVEERVHVMRKTKLAPTVAHGVFNPEFGPAALSNKDPRLNEGV
VLDEVIFSKHKGDTKMSAEDKALFRRCAADYASRLHSVLGTANAPLSIYE
AIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLM
EKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFC
AQMHSNNGPQIGSAVAANPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCS
DAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGMPSGC
SATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDF
EALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYK
PVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLF
EIPSYRSLYLRWVNAVCGDAAAALEH

Ligand information

>5jxs Chain B (length=8)

augggccc

........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5jxs Both cis and trans Activities of Foot-and-Mouth Disease Virus 3D Polymerase Are Essential for Viral RNA Replication.
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): L108 D109 T115 A116 R128 F162 L163 D165 V181 V183 R193 A216 N218 G299 C300 S301 T303 Y336
• Binding residue (residue number reindexed from 1): L108 D109 T115 A116 R128 F162 L163 D165 V181 V183 R193 A216 N218 G299 C300 S301 T303 Y336

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.4.22.28: picornain 3C.
  3.4.22.46: L-peptidase.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:5jxs, PDBe:5jxs, PDBj:5jxs
• PDBsum: 5jxs
• PubMed: 27194768
• UniProt: P03311|POLG_FMDVS Genome polyprotein