Structure of PDB 5jrr Chain A Binding Site BS01

Receptor Information

>5jrr Chain A (length=439) Species: 262724 (Thermus thermophilus HB27)

GPSFPEPKVVRSQGGLLSLKLSATPTPLAIAGQRATLLTYGGSFPGPTLR
VRPRDTVRLTLENRLPEPTNLHWHGLPISPKVDDPFLEIPPGESWTYEFT
VPKELAGTFWYHPHLHGRVAPQLFAGLLGALVVESSLDAIPELREAEEHL
LVLKDLALQGGRPAPHTPMDWMNGKEGDLVLVNGALRPTLVAQKATLRLR
LLNASNARYYRLALQDHPLYLIAADGGFLEEPLEVSELLLAPGERAEVLV
RLRKEGRFLLQALPYDRGAMGMMDMGGMAHAMPQGPSRPETLLYLIAPKN
PKPLPLPKALSPFPTLPAPVVTRRLVLTEDMMAARFFINGQVFDHRRVDL
KGQAQTVEVWEVENQGDMDHPFHLHVHPFQVLSVGGRPFPYRAWKDVVNL
KAGEVARLLVPLREKGRTVFHCHIVEHEDRGMMGVLEVG

Ligand information

• Ligand ID: CU
• InChI: InChI=1S/Cu/q+2
• InChIKey: JPVYNHNXODAKFH-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cu+2]
  CACTVS 3.341: [Cu++]
• Formula: Cu
• Name: COPPER (II) ION
• DrugBank: DB14552
• PDB chain: 5jrr Chain A Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5jrr Preserving metallic sites affected by radiation damage: the CuT2 case in Thermus thermophilus multicopper oxidase
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): H137 H398 H444
• Binding residue (residue number reindexed from 1): H114 H375 H421
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): H95 H97 H135 H137 H393 H396 H398 H444 C445 H446 I447 H450 M455
• Catalytic site (residue number reindexed from 1): H72 H74 H112 H114 H370 H373 H375 H421 C422 H423 I424 H427 M432
• Enzyme Commision number: 1.10.3.2: laccase.

Gene Ontology

Molecular Function

• GO:0005507 copper ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0052716 hydroquinone:oxygen oxidoreductase activity

Cellular Component

• GO:0030288 outer membrane-bounded periplasmic space

External links

• PDB: RCSB:5jrr, PDBe:5jrr, PDBj:5jrr
• PDBsum: 5jrr
• UniProt: Q72HW2