Structure of PDB 5jr6 Chain A Binding Site BS01

Receptor Information
>5jr6 Chain A (length=628) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DNNPAARLEELRTIMKKNKIDVYILINSDEHNSEIINEKDKKIVKITNYS
GADGILIVTKDKPILYVNALYELQAMNELDQNLFTLRISRIDNRDEIFET
ISSLFNTIAFDGKNTSVVFYEKLRKALLNAYPKKKIVEKIIYNNNFDDVL
NFLVLEKSLVEIYPVNNKTLYIHDRKYNGACAGEKIDKLKQSLMYDIKNV
DNLLLSELDEIAYLLNLRGYDYQYSPLFYSYLLFQFDREQDFSKIVFFTT
VKNLPADVKNLLEINKVIVKEYEEIVPYLRDVVIPSIPKDFKKYDISLSP
YINLMIYKLFDRKNVLLQNSPVVKMKAVKNDVEIDNMKQAHILDGLALLQ
FFHWCEQKRKTKELFNETEMSLRHKVDYFRSTKKNFIFPSFSTISASGPN
AAVIHYECTDKTNATIKPAIYLLDSGGQYLHGTTDVTRTTHFGEPTAEEK
RIYTLVLKGHLRLRKVIFASYTNSSALDFIARENLFNNFMDYNHGTGHGV
GLTLNVHEGGCSIGPVGGAPLKKNMVLSNEPGYYMKDKFGVRIENMQYVI
SKEITDTTEYLSFDDLTMYPYEKKLLDFSLLTNQEIKELNEYHTTIRNTL
LPLVKQSPQEYGESVEKYLIEITEPIAI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5jr6 Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		I163 F537 D570 D581 H640 G641 G643 H644 V652 H653 E676
Binding residue
(residue number reindexed from 1)		I35 F391 D424 D435 H494 G495 G497 H498 V506 H507 E530
Enzymatic activity
Enzyme Commision number 3.4.11.9: Xaa-Pro aminopeptidase.
Gene Ontology
Molecular Function
GO:0070006 metalloaminopeptidase activity

View graph for
Molecular Function
External links
PDB RCSB:5jr6, PDBe:5jr6, PDBj:5jr6
PDBsum5jr6
PubMed27462122
UniProtA0A144A2H0|AMPP_PLAF7 Aminopeptidase P (Gene Name=APP)

[Back to BioLiP]