Structure of PDB 5jpx Chain A Binding Site BS01

Receptor Information
>5jpx Chain A (length=45) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5jpx Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5jpx Solution NMR structure of the TRIM21 B-box2 and identification of residues involved in its interaction with the RING domain.
ResolutionN/A
Binding residue
(original residue number in PDB)		C92 H95 C111 C114
Binding residue
(residue number reindexed from 1)		C7 H10 C26 C29
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5jpx, PDBe:5jpx, PDBj:5jpx
PDBsum5jpx
PubMed28753623
UniProtP19474|RO52_HUMAN E3 ubiquitin-protein ligase TRIM21 (Gene Name=TRIM21)

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