Structure of PDB 5jpg Chain A Binding Site BS01

Receptor Information

>5jpg Chain A (length=144) Species: 10116 (Rattus norvegicus)

SSFSTQTPYPNLAVPFFTSIPNGLYPSKSIVISGVVLSDAKRFQINLRCG
GDIAFHLNPRFDENAVVRNTQINNSWGPEERSLPGSMPFSRGQRFSVWIL
CEGHCFKVAVDGQHICEYSHRLMNLPDINTLEVAGDIQLTHVET

Ligand information

• Ligand ID: GLC
• InChI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
• InChIKey: WQZGKKKJIJFFOK-DVKNGEFBSA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: C(C1C(C(C(C(O1)O)O)O)O)O
  OpenEye OEToolkits 1.5.0: C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
  CACTVS 3.341: OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
  CACTVS 3.341: OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
  ACDLabs 10.04: OC1C(O)C(OC(O)C1O)CO
• Formula: C6 H12 O6
• Name: alpha-D-glucopyranose;
  alpha-D-glucose;
  D-glucose;
  glucose
• ChEMBL: CHEMBL423707
• ZINC: ZINC000003861213
• PDB chain: 5jpg Chain C Residue 1

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5jpg Structural Characterization of Rat Galectin-5, an N-Tailed Monomeric Proto-Type-like Galectin.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): R61 E80
• Binding residue (residue number reindexed from 1): R60 E79
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0016936 galactoside binding
• GO:0030246 carbohydrate binding
• GO:0030395 lactose binding

Biological Process

• GO:0010628 positive regulation of gene expression
• GO:0032689 negative regulation of type II interferon production
• GO:0070234 positive regulation of T cell apoptotic process
• GO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation

Cellular Component

• GO:0005634 nucleus
• GO:0005829 cytosol

External links

• PDB: RCSB:5jpg, PDBe:5jpg, PDBj:5jpg
• PDBsum: 5jpg
• PubMed: 34944498
• UniProt: P47967|LEG5_RAT Galectin-5 (Gene Name=Lgals5)