Structure of PDB 5jmq Chain A Binding Site BS01

Receptor Information

>5jmq Chain A (length=339) Species: 10090 (Mus musculus)

DTWQDEEYFDSYGTLKLHLEMLADQPRTTKYHSVILQNKESLKDKVILDV
GCGTGIISLFCAHHARPKAVYAVEASDMAQHTSQLVLQNGFADTITVFQQ
KVEDVVLPEKVDVLVSEWMGTCLLFEFMIESILYARDTWLKGDGIIWPTT
AALHLVPCSAEKDYHSKVLFWDNAYEFNLSALKSLAIKEFFSRPKSNHIL
KPEDCLSEPCTILQLDMRTVQVPDLETMRGELRFDIQKAGTLHGFTAWFS
VYFQSLEEGQPQQVLSTGPLHPTTHWKQTLFMMDDPVPVHTGDVVTGSVV
LQRNPVWRRHMSVSLSWVVTSALDPTSQRVGEKVFPIWW

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 5jmq Chain A Residue 506

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5jmq Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors.
• Resolution: 1.795 Å
• Binding residue (original residue number in PDB): G196 D199
• Binding residue (residue number reindexed from 1): G90 D93
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): D130 E223 E232 H381
• Catalytic site (residue number reindexed from 1): D24 E117 E126 H275

Gene Ontology

Molecular Function

• GO:0008168 methyltransferase activity
• GO:0016274 protein-arginine N-methyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0018216 peptidyl-arginine methylation
• GO:0032259 methylation

External links

• PDB: RCSB:5jmq, PDBe:5jmq, PDBj:5jmq
• PDBsum: 5jmq
• PubMed: 27879050
• UniProt: Q3UKX1