Structure of PDB 5ji2 Chain A Binding Site BS01

Receptor Information

>5ji2 Chain A (length=174) Species: 585055 (Escherichia coli 55989)

TTIVSVRRNGHVVIAGDGQATLGNTVMKGNVKKVRRLYNDKVIAGFAGGT
ADAFTLFELFERKLEMHQGHLVKAAVELAKDWRTDRMLRKLEALLAVADE
TASLIITGNGDVVQPENDLIAIGSGGPYAQAAARALLENTELSAREIAEK
ALDIAGDICIYTNHFHTIEELSYK

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5ji2 Chain A Residue 201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5ji2 A Structurally Dynamic Region of the HslU Intermediate Domain Controls Protein Degradation and ATP Hydrolysis.
• Resolution: 3.307 Å
• Binding residue (original residue number in PDB): C159 I160 T162
• Binding residue (residue number reindexed from 1): C159 I160 T162
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): T1 K33 G45 S124
• Catalytic site (residue number reindexed from 1): T1 K33 G45 S124
• Enzyme Commision number: 3.4.25.2: HslU--HslV peptidase.

Gene Ontology

Molecular Function

• GO:0004298 threonine-type endopeptidase activity
• GO:0008233 peptidase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0030163 protein catabolic process
• GO:0051603 proteolysis involved in protein catabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005839 proteasome core complex
• GO:0009376 HslUV protease complex

External links

• PDB: RCSB:5ji2, PDBe:5ji2, PDBj:5ji2
• PDBsum: 5ji2
• PubMed: 27667691
• UniProt: B7LA29|HSLV_ECO55 ATP-dependent protease subunit HslV (Gene Name=hslV)