Structure of PDB 5jft Chain A Binding Site BS01

Receptor Information
>5jft Chain A (length=238) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HAFRYSLNYPNIGHCIIINNKNFDRRTGMNPRNGTDVDAGNVMNVFRKLG
YIVKVYNDQTVAQIMQVLTTVAHDDHSRCASLVCVLLSHGDEGVFFGTDT
SVDLKSLTSLFRGDRCPSLVGKPKLFFIQACRGTELDPGVETDERIPVEA
DFLYAYSTVPGYYSWRNTMTGSWFIQSLCEMMTKYGSELELLQIMTRVNH
KVALDFESTSNMPGFDAKKQIPCIVSMLTKEMYFTPSE
Ligand information
>5jft Chain F (length=4) Species: 142878 (unidentified 'CNM-group' bacterium HXN600) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DEVD
Receptor-Ligand Complex Structure
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PDB5jft Phage display and structural studies reveal plasticity in substrate specificity of caspase-3a from zebrafish.
Resolution2.28 Å
Binding residue
(original residue number in PDB)		R67 H124 Q164 C166 Y209 S210 W211 R212 N213 T214 S254
Binding residue
(residue number reindexed from 1)		R32 H89 Q129 C131 Y163 S164 W165 R166 N167 T168 S208
Enzymatic activity
Catalytic site (original residue number in PDB) N65 P66 H124 G125 C166 R167
Catalytic site (residue number reindexed from 1) N30 P31 H89 G90 C131 R132
Enzyme Commision number 3.4.22.56: caspase-3.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5jft, PDBe:5jft, PDBj:5jft
PDBsum5jft
PubMed27577093
UniProtA0A2R8QUC0

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