Structure of PDB 5jel Chain A Binding Site BS01

Receptor Information

>5jel Chain A (length=234) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTL
PGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGH
CHTYWAVSEELLPNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGR
SPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLRALVEMARVGGASSLE
NTVDLHISNSHPLSLTSDQYKAYLQDLVEGMDFQ

Ligand information

>5jel Chain B (length=14) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

SPASLASNLEISQS

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5jel Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Resolution	1.6 Å
Binding residue (original residue number in PDB)	Y260 R285 H288 H290 Y292 K313 G349 E350 S351
Binding residue (residue number reindexed from 1)	Y72 R97 H100 H102 Y104 K125 G161 E162 S163

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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Molecular Function

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Biological Process

External links

PDB	RCSB:5jel, PDBe:5jel, PDBj:5jel
PDBsum	5jel
PubMed	27302953
UniProt	Q14653\|IRF3_HUMAN Interferon regulatory factor 3 (Gene Name=IRF3)

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