Structure of PDB 5jej Chain A Binding Site BS01

Receptor Information
>5jej Chain A (length=234) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTL
PGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGH
CHTYWAVSEELLPNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGR
SPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLRALVEMARVGGASSLE
NTVDLHISNSHPLSLTSDQYKAYLQDLVEGMDFQ
Ligand information
Receptor-Ligand Complex Structure
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PDB5jej Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		Y260 C267 R285 H288 H290 K313 G349 E350 S351
Binding residue
(residue number reindexed from 1)		Y72 C79 R97 H100 H102 K125 G161 E162 S163
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5jej, PDBe:5jej, PDBj:5jej
PDBsum5jej
PubMed27302953
UniProtQ14653|IRF3_HUMAN Interferon regulatory factor 3 (Gene Name=IRF3)

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