Structure of PDB 5jbg Chain A Binding Site BS01

Receptor Information
>5jbg Chain A (length=661) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SELHGYQLEAVAPALRGRNSIVWLPTGAGKTRAAVHVCRRHLEGRRGGRV
AVLVNKVHLVQQHLEKEFHVLRDAFKVTAVSGDSSHKCFFGQLAKGSDVV
ICTAQILQNALLSGEEEARVELTDFSLLVIDECHHTQKEAVYNKIMLSYL
QKKLSGQRDLPQILGLTASPGTGGETSFEGAVEHILQICANLDTEVIASA
QEVPQPTKQYDLCQEREQDPFGQRLKKIMAQIQEHMEMPELPQNFGTQVY
EQRIVELENRAAERFCRKTRVCALHLRRYNDALLINDTVRMMDAFQCLQQ
FYADKKDPTERFLATTFEENRATLQALAGDQRYENPRLSKLEEILQEHFQ
PGSSRGIVFTKTRQSAHSLLSWLQDTAGLCGQHIRAAVLTGSGHSNQAKG
MTQNEQQDVITLFRYGELNLLFSTSVAEEGLDIPECNIVVRYGLMTNEIA
MVQAQGRARAQNSMYSVLAKANSREVYREQLNESLVGLMERAIRAVQAMP
ERKYRLKIVELQRNAVLSWQVKEARSSERRQLHDPDDVYFHCVNCNVAVC
RGSDIRTVEAMHHVNINPNFRFYYTVSSGKIHFERTFRDWEPGCRIVCSE
CRQEWGMEMIYRNVTLPILSIKNFVVVTPDEKKKYKKWSTVTFPIEEFSY
LEYCSSTQDES
Ligand information
>5jbg Chain X (length=23) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggagcgugccgggcacgcuccgg
<<<<<<<<<<.>>>>>>>>>>..
Receptor-Ligand Complex Structure
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PDB5jbg Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
Resolution2.0 Å
Binding residue
(original residue number in PDB)
K56 V57 V80 S81 G82 S84 K87 C88 F89 F90 L93 T103 Q105 I106 N109 K138 E139 A140 Q256 E259 Q260 V263 E264 K373 T374 R375 T402 G403 S404 G405 H406 S407 N408 T436 M457 R486 M573 H574 F595 R597 F599 R600 R607 M619 S632 K645 K648 S651
Binding residue
(residue number reindexed from 1)
K56 V57 V80 S81 G82 S84 K87 C88 F89 F90 L93 T103 Q105 I106 N109 K138 E139 A140 Q248 E251 Q252 V255 E256 K361 T362 R363 T390 G391 S392 G393 H394 S395 N396 T424 M445 R474 M561 H562 F583 R585 F587 R588 R595 M607 S620 K633 K636 S639
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0045087 innate immune response
Cellular Component
GO:0005737 cytoplasm

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:5jbg, PDBe:5jbg, PDBj:5jbg
PDBsum5jbg
PubMed27203181
UniProtG0YYQ5

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