Structure of PDB 5jac Chain A Binding Site BS01

Receptor Information

>5jac Chain A (length=173) Species: 8400 (Aquarana catesbeiana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VSQVRQNYHSDCEAAVNRMLNLELYASYTYSSMYAFFDRDDVALHNVAEF
FKEHSHAEREHAEKFMKYQNKRGGRVVLQDIKKPERDEWGNTLEAMQAAL
QLEKTVNQALLDLHKLATDKVDPHLCDFLESEYLEAQVKAIKRIGDFITN
LKRLGLPENGMGEYLFDKHSVKE

Ligand information

InChI=1S/Fe/q+2

CWYNVVGOOAEACU-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Fe+2]
CACTVS 3.341	[Fe++]

Formula

Name

FE (II) ION

PDB chain

5jac Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5jac Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic Cavity.
Resolution	1.18 Å
Binding residue (original residue number in PDB)	E23 E58 H61
Binding residue (residue number reindexed from 1)	E23 E58 H61
Annotation score	5

Enzymatic activity

Enzyme Commision number

1.16.3.1: ferroxidase.

Gene Ontology

	Molecular Function
GO:0004322	ferroxidase activity
GO:0008198	ferrous iron binding
GO:0008199	ferric iron binding
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006826	iron ion transport
GO:0006879	intracellular iron ion homeostasis
GO:0006880	intracellular sequestering of iron ion

	Cellular Component
GO:0005737	cytoplasm

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External links

PDB	RCSB:5jac, PDBe:5jac, PDBj:5jac
PDBsum	5jac
PubMed	27650996
UniProt	P07798\|FRI2_AQUCT Ferritin, middle subunit

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