Structure of PDB 5j8c Chain A Binding Site BS01

Receptor Information
>5j8c Chain A (length=272) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYR
FHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHK
TLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVASILTLPPYQ
RRGYGKFLIAFSYELSKLESTVGSPQKPLSDLGKLSYRSYWSWVLLEILR
DFGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEH
LKSAQYKKPPITVDSVCLKWAP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5j8c Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5j8c Structural and Functional Role of Acetyltransferase hMOF K274 Autoacetylation.
Resolution2.17 Å
Binding residue
(original residue number in PDB)		C210 C213 H226 C230
Binding residue
(residue number reindexed from 1)		C36 C39 H52 C56
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) S316 Q350
Catalytic site (residue number reindexed from 1) S142 Q176
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5j8c, PDBe:5j8c, PDBj:5j8c
PDBsum5j8c
PubMed27382063
UniProtQ9H7Z6|KAT8_HUMAN Histone acetyltransferase KAT8 (Gene Name=KAT8)

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