Structure of PDB 5j3r Chain A Binding Site BS01

Receptor Information
>5j3r Chain A (length=114) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AFNVQKEYSLILDLSPIIIFSKSTCSYSKGMKELLENEYQFIPNYYIIEL
DKHGHGEELQEYIKLVTGRGTVPNLLVNGVSRGGNEEIKKLHTQGKLLES
LQVWSDGKFSVEQR
Ligand information
Ligand IDFES
InChIInChI=1S/2Fe.2S
InChIKeyNIXDOXVAJZFRNF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04[Fe]1S[Fe]S1
CACTVS 3.341
OpenEye OEToolkits 1.5.0		S1[Fe]S[Fe]1
FormulaFe2 S2
NameFE2/S2 (INORGANIC) CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain5j3r Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5j3r Crystal structure of yeast monothiol glutaredoxin Grx6 in complex with a glutathione-coordinated [2Fe-2S] cluster
Resolution2.46 Å
Binding residue
(original residue number in PDB)		C136 S137 Y138
Binding residue
(residue number reindexed from 1)		C25 S26 Y27
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004362 glutathione-disulfide reductase (NADPH) activity
GO:0005506 iron ion binding
GO:0015038 glutathione disulfide oxidoreductase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0006879 intracellular iron ion homeostasis
GO:0016226 iron-sulfur cluster assembly
GO:0034599 cellular response to oxidative stress
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0000324 fungal-type vacuole
GO:0005737 cytoplasm
GO:0005773 vacuole
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005796 Golgi lumen
GO:0005801 cis-Golgi network
GO:0016020 membrane
GO:1990229 iron-sulfur cluster assembly complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5j3r, PDBe:5j3r, PDBj:5j3r
PDBsum5j3r
PubMed27710937
UniProtQ12438|GLRX6_YEAST Monothiol glutaredoxin-6 (Gene Name=GRX6)

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