Structure of PDB 5iza Chain A Binding Site BS01

Receptor Information
>5iza Chain A (length=341) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HHHMLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAVCV
LMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAG
MALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLS
WRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTEN
KADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDH
RQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMG
AVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKDANIM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5iza Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Resolution1.5 Å
Binding residue
(original residue number in PDB)		F458 M503 N507 F510 G511 K516 Q542 R549 N550 W553 W593 N594
Binding residue
(residue number reindexed from 1)		F56 M101 N105 F108 G109 K114 Q140 R147 N148 W151 W191 N192
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008013 beta-catenin binding
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5iza, PDBe:5iza, PDBj:5iza
PDBsum5iza
PubMed28759015
UniProtP25054|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

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