Structure of PDB 5iz9 Chain A Binding Site BS01

Receptor Information
>5iz9 Chain A (length=328) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLHLLEQIRAYCETCWEWQEAHEPGNPMPAPVEHQICPAVCVLMKLSFDE
EHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTF
GDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSK
KTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVD
GALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENN
CLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNL
IHSKHKMIAMGSAAALRNLMANRPAKYK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5iz9 Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Resolution2.93 Å
Binding residue
(original residue number in PDB)		T506 N507 F510 G511 K516 R549 N550 W553 S590 W593 N594
Binding residue
(residue number reindexed from 1)		T96 N97 F100 G101 K106 R139 N140 W143 S180 W183 N184
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008013 beta-catenin binding
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5iz9, PDBe:5iz9, PDBj:5iz9
PDBsum5iz9
PubMed28759015
UniProtP25054|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

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