Structure of PDB 5iz8 Chain A Binding Site BS01

Receptor Information
>5iz8 Chain A (length=343) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HHHHHMLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRY
AGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRN
LSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCT
ENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNE
DHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWD
MGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKDANIM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5iz8 Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Resolution3.06 Å
Binding residue
(original residue number in PDB)		F458 N507 F510 G511 K516 R549 N550 W553 S590 W593 N594
Binding residue
(residue number reindexed from 1)		F58 N107 F110 G111 K116 R149 N150 W153 S190 W193 N194
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008013 beta-catenin binding
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5iz8, PDBe:5iz8, PDBj:5iz8
PDBsum5iz8
PubMed28759015
UniProtP25054|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

[Back to BioLiP]