Structure of PDB 5ixi Chain A Binding Site BS01

Receptor Information

>5ixi Chain A (length=436) Species: 9606 (Homo sapiens)

VEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENT
KLWYAPNRTITVMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPTPLLDAS
SLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMM
KKMSYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVS
THDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSVLYYEVMV
TGNLGIQWRHKPEEWNNFSFFPEITHIVIKESVVSINKQDNKKMELKLSS
HEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEY
AINKLRQEYVLRWSCTDFDNILMTNFQIEVQKGRYSLHGSDRSFPSLGDL
MSHLKKQILRTDNISFMLKRCCQPKPREISNLLVAT

Ligand information

>5ixi Chain B (length=29) Species: 9606 (Homo sapiens)

TLMGNPWFQRKKLPSVLLFKKPSPFIFIS

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5ixi The Structural Basis for Class II Cytokine Receptor Recognition by JAK1.
• Resolution: 2.57 Å
• Binding residue (original residue number in PDB): Q180 H183 E186 N187 E188 L190 G191 L195 R232 N233 L235 T236 R239 I240 D246 F247 F251 S259 V261 K269
• Binding residue (residue number reindexed from 1): Q127 H130 E133 N134 E135 L137 G138 L142 R170 N171 L173 T174 R177 I178 D184 F185 F189 S197 V199 K207

Enzymatic activity

• Enzyme Commision number: 2.7.10.2: non-specific protein-tyrosine kinase.

Gene Ontology

Molecular Function

• GO:0004715 non-membrane spanning protein tyrosine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation
• GO:0035556 intracellular signal transduction

Cellular Component

• GO:0005856 cytoskeleton
• GO:0016020 membrane

External links

• PDB: RCSB:5ixi, PDBe:5ixi, PDBj:5ixi
• PDBsum: 5ixi
• PubMed: 27133025
• UniProt: P23458|JAK1_HUMAN Tyrosine-protein kinase JAK1 (Gene Name=JAK1)