Structure of PDB 5ixd Chain A Binding Site BS01

Receptor Information

>5ixd Chain A (length=420) Species: 9606 (Homo sapiens)

VEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENT
KLWYAPNRTITVMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPTPLLDAS
SLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMM
KKMQLPELPISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKT
ICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSL
YYEVMVTGNLGIQWRHKPNEEWNNFSFFPEITHIVIKESVVSINKQDNKK
MELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCH
GPICTEYAINKLRQEYVLRWSCTDFDNILIEVQKRYSLHGSDRSFPSLGD
LMSHLCQPKPREISNLLVAT

Ligand information

>5ixd Chain B (length=21) Species: 9606 (Homo sapiens)

KTLMGNPWFQRAKMPRALDFS

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5ixd The Structural Basis for Class II Cytokine Receptor Recognition by JAK1.
• Resolution: 2.85 Å
• Binding residue (original residue number in PDB): Q180 H183 D184 E186 N187 E188 G191 V194 L195 N233 L235 R239 I240 F247 E250 F251 V261 K269
• Binding residue (residue number reindexed from 1): Q127 H130 D131 E133 N134 E135 G138 V141 L142 N178 L180 R184 I185 F192 E195 F196 V206 K214

Enzymatic activity

• Enzyme Commision number: 2.7.10.2: non-specific protein-tyrosine kinase.

Gene Ontology

Molecular Function

• GO:0004715 non-membrane spanning protein tyrosine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation
• GO:0035556 intracellular signal transduction

Cellular Component

• GO:0005856 cytoskeleton
• GO:0016020 membrane

External links

• PDB: RCSB:5ixd, PDBe:5ixd, PDBj:5ixd
• PDBsum: 5ixd
• PubMed: 27133025
• UniProt: P23458|JAK1_HUMAN Tyrosine-protein kinase JAK1 (Gene Name=JAK1)