Structure of PDB 5ixb Chain A Binding Site BS01

Receptor Information
>5ixb Chain A (length=105) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPKLADRKLCADQECSHPISMAVALQDYMAPDCRFLTIHRGQVVYVFSKL
KGRGRLFWGGSVQGDYYGDLAARLGYFPSSIVREDQTLKPGKVDVKTDKW
DFYCQ
Ligand information
Ligand IDLGA
InChIInChI=1S/C4H5N3/c5-4-6-2-1-3-7-4/h1-3H,(H2,5,6,7)
InChIKeyLJXQPZWIHJMPQQ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Nc1ncccn1
ACDLabs 10.04n1cccnc1N
OpenEye OEToolkits 1.5.0c1cnc(nc1)N
FormulaC4 H5 N3
NamePYRIMIDIN-2-AMINE
ChEMBLCHEMBL88580
DrugBank
ZINCZINC000000967472
PDB chain5ixb Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5ixb Small Molecules Antagonise the MIA-Fibronectin Interaction in Malignant Melanoma.
Resolution1.39 Å
Binding residue
(original residue number in PDB)		L76 G77 Y78 D103
Binding residue
(residue number reindexed from 1)		L74 G75 Y76 D101
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008083 growth factor activity
Biological Process
GO:0007165 signal transduction
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space

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Biological Process
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Cellular Component
External links
PDB RCSB:5ixb, PDBe:5ixb, PDBj:5ixb
PDBsum5ixb
PubMed27151361
UniProtQ16674|MIA_HUMAN Melanoma-derived growth regulatory protein (Gene Name=MIA)

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