Structure of PDB 5iud Chain A Binding Site BS01

Receptor Information
>5iud Chain A (length=859) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EQVFHFYWLDAYEDQYNQPGVVFLFGKVWIESAETHVSCCVMVKNIERTL
YFLPREMKIDLNTGKETGTPISMKDVYEEFDEKIATKYKIMKFKSKPVEK
NYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTNTSSLELF
LMNRKIKGPCWLEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKDVSPPPL
VVMAFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVS
KPKDCIFPYAFKEVIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGH
NIYGFELEVLLQRINVCKAPHWSKIGRLKRSNMPKLGERNATCGRMICDV
EISAKELIRCKSYHLSELVQQILKTERVVIPMENIQNMYSESSQLLYLLE
HTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFLLL
HAFYENNYIVPDKQIKAAYAGGLVLDPKVGFYDKFILLLDFNSLYPSIIQ
EFNICFTTVQRIPELPDPSLEMGILPREIRKLVERRKQVKQLMKQQDLNP
DLILQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTYKGREILMH
TKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLL
EIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDWCD
LAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEIN
KALTKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNL
TASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIA
TWLGLDPTQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5iud Human DNA polymerase alpha in binary complex with a DNA:DNA template-primer.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		R784 S785 A837 Y839 A840 G841 G842 G958 F962 K1052 K1054 R1081 D1148 S1151 S1189 R1222
Binding residue
(residue number reindexed from 1)		R441 S442 A467 Y469 A470 G471 G472 G572 F576 K666 K668 R695 D762 S765 S803 R836
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:1902975 mitotic DNA replication initiation

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Molecular Function
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Biological Process
External links
PDB RCSB:5iud, PDBe:5iud, PDBj:5iud
PDBsum5iud
PubMed27032819
UniProtP09884|DPOLA_HUMAN DNA polymerase alpha catalytic subunit (Gene Name=POLA1)

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