Structure of PDB 5itu Chain A Binding Site BS01

Receptor Information
>5itu Chain A (length=268) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEGPELHLASQFVNEACRALVFGGCVEKSSVSRNPEVPFESSAYRISASA
RGKELRLILSPLPGAQPQQEPLALVFRFGMSGSFQLVPREELPRHAHLRF
YTAPPGPRLALCFVDIRRFGRWDLGGKWQPGRGPCVLQEYQQFRENVLRN
LADKAFDRPICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARSVLEAL
NPDLLELCHSVPKEVVQLGGKGYGSSGEEDFAAFRAWLRCYGMPGMSSLQ
DRHGRTIWFQGDPGPLAP
Ligand information
Receptor-Ligand Complex Structure
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PDB5itu Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair
Resolution2.41 Å
Binding residue
(original residue number in PDB)		E3 K54 R78 G80 M81 R118 F120 R133 Q168 G175 N176 Y244 Y263 H275 R277 T278
Binding residue
(residue number reindexed from 1)		E2 K53 R77 G79 M80 R117 F119 R132 Q167 G174 N175 Y223 Y241 H253 R255 T256
Enzymatic activity
Enzyme Commision number 3.2.2.-
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0016829 lyase activity
GO:0019104 DNA N-glycosylase activity
GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0006979 response to oxidative stress
GO:0032074 negative regulation of nuclease activity
GO:0045008 depyrimidination
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005856 cytoskeleton

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5itu, PDBe:5itu, PDBj:5itu
PDBsum5itu
PubMed27354518
UniProtQ96FI4|NEIL1_HUMAN Endonuclease 8-like 1 (Gene Name=NEIL1)

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