Structure of PDB 5inq Chain A Binding Site BS01

Receptor Information
>5inq Chain A (length=255) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KGLEDSSTISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIP
PYCAYLKKRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKMM
RNLLCVNVSLGGNEFCLMTSHLESTREHSAERIRQLKTVLGKMQEAPDST
TVIFAGDTNLRDQEVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNNL
RIPAAYKHRFDRIFFRAEEGHLIPQSLDLVGLEKLDCGRFPSDHWGLLCT
LNVVL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5inq Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
Resolution1.848 Å
Binding residue
(original residue number in PDB)		E162 H236 S239 T240 R241 R276 W307 L315 I317 Y321
Binding residue
(residue number reindexed from 1)		E47 H121 S124 T125 R126 R161 W192 L200 I202 Y206
Enzymatic activity
Enzyme Commision number 3.1.4.-
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:5inq, PDBe:5inq, PDBj:5inq
PDBsum5inq
PubMed27060144
UniProtQ9JJX7|TYDP2_MOUSE Tyrosyl-DNA phosphodiesterase 2 (Gene Name=Tdp2)

[Back to BioLiP]