Structure of PDB 5inm Chain A Binding Site BS01

Receptor Information
>5inm Chain A (length=246) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
STISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIPPYCAYL
KKRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKMMRNLLCV
NVSLGGNEFCLMTSHLESTREHSAERIRQLKTVLGKMQEAPDSTTVIFAG
DTNLRDQEVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNNLRIPAAY
KHRFDRIFFRAEHLIPQSLDLVGLEKLDCGRFPSDHWGLLCTLNVV
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5inm Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5inm Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		D132 E162
Binding residue
(residue number reindexed from 1)		D11 E41
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.4.-
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:5inm, PDBe:5inm, PDBj:5inm
PDBsum5inm
PubMed27060144
UniProtQ9JJX7|TYDP2_MOUSE Tyrosyl-DNA phosphodiesterase 2 (Gene Name=Tdp2)

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