Structure of PDB 5ijx Chain A Binding Site BS01

Receptor Information
>5ijx Chain A (length=365) Species: 222929 (Coccidioides posadasii C735 delta SOWgp) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RHITQQHLRRTAEAEEQWKLQAKEIEAGRKQSFLSFLEERGLVNSVVGQR
DALDKLITRKRVGFYAGVDPTAPSLHIGHMLPFMILGWAYVHGLKAVFLI
GGSTAKIGDPTGRMDGATRRANIANIHLQLKRLGFSFEKYGRKHGFEWEW
AWRRALENNNTWWNKQSLKEVMEVLGTSLRLGPMLGRDYVKSRLASGEGM
SIAEFCYPIMQGWDFWYLFQRKVQVQVGGSDQYGNILFGMDAIKGILKAN
PESEWAPKKDEDPDLANPYGITTPLLTTASGEKAVWLDKDMTSCYDLYQY
FVRVADSDVERYLKMFTFVPTPAIKELMEEHAKDPSKRVAQHKLAREFVE
LIHGSLSAEQAAKDH
Ligand information
Ligand IDTYR
InChIInChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1
InChIKeyOUYCCCASQSFEME-QMMMGPOBSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(N)Cc1ccc(O)cc1
OpenEye OEToolkits 1.5.0c1cc(ccc1C[C@@H](C(=O)O)N)O
OpenEye OEToolkits 1.5.0c1cc(ccc1CC(C(=O)O)N)O
CACTVS 3.341N[CH](Cc1ccc(O)cc1)C(O)=O
CACTVS 3.341N[C@@H](Cc1ccc(O)cc1)C(O)=O
FormulaC9 H11 N O3
NameTYROSINE
ChEMBLCHEMBL925
DrugBankDB00135
ZINCZINC000000266964
PDB chain5ijx Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5ijx Crystal Structure of a C-terminally truncated Coccidioides posadasii mitochondrial tyrosyl-tRNA synthetase
Resolution2.63 Å
Binding residue
(original residue number in PDB)		G116 D118 D158 Q266 D269 Q287
Binding residue
(residue number reindexed from 1)		G67 D69 D109 Q211 D214 Q232
Annotation score5
Enzymatic activity
Catalytic site (original residue number in PDB) T120 H125 H128 R162 Q266 D286 K338
Catalytic site (residue number reindexed from 1) T71 H76 H79 R113 Q211 D231 K283
Enzyme Commision number 6.1.1.1: tyrosine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004831 tyrosine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006437 tyrosyl-tRNA aminoacylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5ijx, PDBe:5ijx, PDBj:5ijx
PDBsum5ijx
PubMed
UniProtC5P455

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