Structure of PDB 5ic6 Chain A Binding Site BS01

Receptor Information
>5ic6 Chain A (length=140) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGF
DVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGV
TPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQ
Ligand information
Receptor-Ligand Complex Structure
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PDB5ic6 Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		R87 H144 Q184 C186
Binding residue
(residue number reindexed from 1)		R31 H88 Q128 C130
Enzymatic activity
Catalytic site (original residue number in PDB) G85 V86 H144 G145 C186
Catalytic site (residue number reindexed from 1) G29 V30 H88 G89 C130
Enzyme Commision number 3.4.22.60: caspase-7.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5ic6, PDBe:5ic6, PDBj:5ic6
PDBsum5ic6
PubMed27367566
UniProtP55210|CASP7_HUMAN Caspase-7 (Gene Name=CASP7)

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