Structure of PDB 5i7m Chain A Binding Site BS01

Receptor Information
>5i7m Chain A (length=167) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PNSLDQIDLLSTKSFPPCMRQLHKALRENHHLRHGGRMQYGLFLKGIGLT
LEQALQFWKDKGFSYNIRHSDYTPFSCLKIILSNPPSQGDYHGCPFRHSD
PELLKQKLQSYKISPGGISQILDLVKGTHYQVACQKYFEMIHNVDDCGFS
LNHPNQFFCESQRILNG
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain5i7m Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5i7m The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport.
Resolution1.93 Å
Binding residue
(original residue number in PDB)		P285 C287 C367 C384 F386 C424
Binding residue
(residue number reindexed from 1)		P16 C18 C77 C94 F96 C134
Annotation score4
Enzymatic activity
Enzyme Commision number 2.7.7.-
Gene Ontology
Biological Process
GO:0006269 DNA replication, synthesis of primer

View graph for
Biological Process
External links
PDB RCSB:5i7m, PDBe:5i7m, PDBj:5i7m
PDBsum5i7m
PubMed28232525
UniProtP49643|PRI2_HUMAN DNA primase large subunit (Gene Name=PRIM2)

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