Structure of PDB 5i49 Chain A Binding Site BS01

Receptor Information
>5i49 Chain A (length=471) Species: 5691 (Trypanosoma brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VRLYSCDACPHAVFTTHAALLAHAEEHHADLLPDHARLRRIAQKLNPVWN
RALNARRNTITSWGKKIFHVAAQRDAGESKMQEAHRARAQLECVVRRWHD
KARVFIFGSSVAMGVWDGTADIDFAVVDVDAMERGSWPPLEKNAVRSITE
LLRRVGFSFVNLEPISHARVPIIKHHASSPDVVARSIRFILNGPATREDR
LLLEGSVRDAVGPTGVQQVWWNRTSDMMSATLESTTAAVRAAMCSPALAS
ASLRTKVQPAHDECRPELYNIDFDLSFRAFGIRNSTLLRKYLLSHPCARP
GAIVLKDWSKTSGVNNSVNGYFTSYAINIMWIYYLVQKGYVPYVDPLEIP
ESLVNYTDFDPRYTPMIDPEITNTEREELYKAAGDMLVGFFYFYSFEFDW
GHNVISLNRPGITTKRMLGWHVEDVHPTRYELCIEDPYEENLNLGRHIGV
TKSLRVRTELYRGLLSLLKEG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5i49 Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5i49 RNA Editing TUTase 1: structural foundation of substrate recognition, complex interactions and drug targeting.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		C195 C198 H212 H217
Binding residue
(residue number reindexed from 1)		C6 C9 H23 H28
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.52: RNA uridylyltransferase.
External links
PDB RCSB:5i49, PDBe:5i49, PDBj:5i49
PDBsum5i49
PubMed27744351
UniProtQ8WQX5|TUT1_TRYBB Terminal uridylyltransferase 1 (Gene Name=KRET1)

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