Structure of PDB 5i0a Chain A Binding Site BS01

Receptor Information
>5i0a Chain A (length=142) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CLAEGTRIFDPVTGTTHRIEDVVDGRKPIHVVAAAKDGTLHARPVVSWFD
QGTRDVIGLRIAGGAILWATPDHKVLTEYGWRAAGELRKGDRVAVRDVET
GELRYSVIREVLPTRRARTFDLEVEELHTLVAEGVVVHACSP
Ligand information
Ligand IDCPT
InChIInChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
InChIKeyLXZZYRPGZAFOLE-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6[NH3][Pt]([NH3])(Cl)Cl
ACDLabs 12.01[Pt](N)(N)(Cl)Cl
CACTVS 3.385N|[Pt](|N)(Cl)Cl
FormulaCl2 H6 N2 Pt
NameCisplatin;
diammine(dichloro)platinum
ChEMBL
DrugBankDB00515
ZINC
PDB chain5i0a Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5i0a Structural insights into protein splicing inhibition by platinum therapeutics as potential anti-microbials
Resolution1.5 Å
Binding residue
(original residue number in PDB)		H439 C441
Binding residue
(residue number reindexed from 1)		H138 C140
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Biological Process
GO:0016539 intein-mediated protein splicing

View graph for
Biological Process
External links
PDB RCSB:5i0a, PDBe:5i0a, PDBj:5i0a
PDBsum5i0a
PubMed
UniProtP9WHJ3|RECA_MYCTU Protein RecA (Gene Name=recA)

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