Structure of PDB 5huk Chain A Binding Site BS01

Receptor Information
>5huk Chain A (length=388) Species: 1589662 (Influenza A virus (A/Northern pintail/Washington/40964/2014(H5N2))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AEYRNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREPYVSCSPGKCYQ
FALGQGTTLNNKHSNGTIHDRIPHRTLLMSELGVPFHLGTKQVCIAWSSS
SCHDGKAWLHVCVTGDDRNATASFIYDGMLADSIGSWSQNILRTQESECV
CINGTCTVVMTDGSASGRADTRILFIKEGKIVHISPLSGSAQHIEECSCY
PRYPDVRCVCRDNWKGSNRPVIDINMADYSIDSSYVCSGLVGDTPRNDDS
SSSSNCRDPNNERGNPGVKGWAFDNGNDVWMGRTISEDSRSGYETFRVTD
GWTTANSKSQVNRQIIVDNNNWSGYSGIFSVEGKSCINRCFYVELIRGRP
QETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPI
Ligand information
Ligand IDBMA
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6-/m1/s1
InChIKeyWQZGKKKJIJFFOK-RWOPYEJCSA-N
SMILES
SoftwareSMILES
CACTVS 3.341OC[C@H]1O[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@@H]([C@@H](O1)O)O)O)O)O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namebeta-D-mannopyranose;
beta-D-mannose;
D-mannose;
mannose
ChEMBL
DrugBank
ZINCZINC000003830679
PDB chain5huk Chain K Residue 3 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5huk Molecular Characterizations of Surface Proteins Hemagglutinin and Neuraminidase from Recent H5Nx Avian Influenza Viruses.
Resolution2.45 Å
Binding residue
(original residue number in PDB)		Q391 V392 R394
Binding residue
(residue number reindexed from 1)		Q310 V311 R313
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) D151 E277 R292 R371 Y406
Catalytic site (residue number reindexed from 1) D70 E196 R211 R290 Y325
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0046761 viral budding from plasma membrane
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5huk, PDBe:5huk, PDBj:5huk
PDBsum5huk
PubMed27053557
UniProtA0A0C4WXC5

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