Structure of PDB 5huc Chain A Binding Site BS01

Receptor Information

>5huc Chain A (length=449) Species: 1718 (Corynebacterium glutamicum)

DLPPLPEGMQQQFEDTISRDAKQQPTWDRAQAENVRKILESVPPIVVAPE
VLELKQKLADVANGKAFLLQGGDCAETFESNTEPHIRANVKTLLQMAVVL
TYGASTPVIKMARIAGQYAKPRSSDLDGNGLPNYRGDIVNGVEATPEARR
HDPARMIRAYANASAAMNLVRALTSSGTADLYRLSEWNREFVANSPAGAR
YEALAREIDSGLRFMEACGVSDESLRAADIYCSHEALLVDYERSMLRLAT
DEEGNEELYDLSAHQLWIGERTRGMDDFHVNFASMISNPIGIKIGPGITP
EEAVAYADKLDPNFEPGRLTIVARMGHDKVRSVLPGVIQAVEASGHKVIW
QSDPMHGNTFTASNGYKTRHFDKVIDEVQGFFEVHRALGTHPGGIHIEFT
GEDVTECLGGAEDITDVDLPGRYESACDPRLNTQQSLELAFLVAEMLRN

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 5huc Chain A Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5huc Inter-Enzyme Allosteric Regulation of Chorismate Mutase in Corynebacterium glutamicum: Structural Basis of Feedback Activation by Trp.
• Resolution: 2.45 Å
• Binding residue (original residue number in PDB): C97 H379 E421 D451
• Binding residue (residue number reindexed from 1): C74 H356 E398 D428
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase.

Gene Ontology

Molecular Function

• GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity
• GO:0016740 transferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0008652 amino acid biosynthetic process
• GO:0009073 aromatic amino acid family biosynthetic process
• GO:0009423 chorismate biosynthetic process

External links

• PDB: RCSB:5huc, PDBe:5huc, PDBj:5huc
• PDBsum: 5huc
• PubMed: 29178787
• UniProt: Q8NNL5