Structure of PDB 5hto Chain A Binding Site BS01

Receptor Information
>5hto Chain A (length=302) Species: 5855 (Plasmodium vivax) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPKIVLVGSGMIGGVMATLIVQKNLGDVVMFDVVKNMPQGKALDTSHSNV
MAYSNCKVTGSNSYDDLKGADVVIVTAGFTKAPLLPLNNKIMIEIGGHIK
NLCPNAFIIVVTNPVDVMVQLLFEHSGVPKNKIIGLGGVLDTSRLKYYIS
QKLNVCPRDVNALIVGAHGNKMVLLKRYITVGGIPLQEFINNKKITDEEV
EGIFDRTVNTALEIVNLLASPYVAPAAAIIEMAESYLKDIKKVLVCSTLL
EGQYGHSNIFGGTPLVIGGTGVEQVIELQLNAEEKTKFDEAVAETKRMKA
LI
Ligand information
Receptor-Ligand Complex Structure
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PDB5hto Crystal structure of a DNA aptamer bound to PvLDH elucidates novel single-stranded DNA structural elements for folding and recognition
Resolution1.9 Å
Binding residue
(original residue number in PDB)		M14 V36 F82 T83 L98 L232 S234
Binding residue
(residue number reindexed from 1)		M11 V33 F79 T80 L84 L218 S220
Enzymatic activity
Catalytic site (original residue number in PDB) D155 R158 H182
Catalytic site (residue number reindexed from 1) D141 R144 H168
Enzyme Commision number 1.1.1.27: L-lactate dehydrogenase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0004459 L-lactate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0006089 lactate metabolic process
GO:0006090 pyruvate metabolic process
GO:0019752 carboxylic acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5hto, PDBe:5hto, PDBj:5hto
PDBsum5hto
PubMed27725738
UniProtQ4PRK9

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