Structure of PDB 5htb Chain A Binding Site BS01

Receptor Information

>5htb Chain A (length=328) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDL
VNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYP
PLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLS
SLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTLN
GKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFD
IYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQI
KRKIQEFHRTMLNFSSATDLLCQHSLFK

Ligand information

>5htb Chain B (length=7) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ARKKQTA

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5htb Co-crystal structures of the protein kinase haspin with bisubstrate inhibitors.
Resolution	1.7 Å
Binding residue (original residue number in PDB)	V494 N522 H651 D687 L690 D707 D709 Q718 Y722
Binding residue (residue number reindexed from 1)	V24 N52 H181 D217 L220 D237 D239 Q248 Y252

Enzymatic activity

Enzyme Commision number

2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

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Molecular Function

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Biological Process

External links

PDB	RCSB:5htb, PDBe:5htb, PDBj:5htb
PDBsum	5htb
PubMed	27139824
UniProt	Q8TF76\|HASP_HUMAN Serine/threonine-protein kinase haspin (Gene Name=HASPIN)

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