Structure of PDB 5hsw Chain A Binding Site BS01

Receptor Information
>5hsw Chain A (length=428) Species: 435895 (Human herpesvirus 8 type M) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TPADLFSEDAVLASLSFSKFLKHAKVRDWCAQAKIQPSMPALRMAYNYFL
FSKVGEFIGSEDVCNFFVDRVFGGVRLLDVASVYAACSQMNAHQRHHICC
LVERATSSQSLNPVWDALRDGIISSSKFHWAVKQQNKIFSPPLAFGLRCE
EVVKTLLATLLHPDETNCLDYGFMQSPQNGIFGVSLDFAANVKTDTGRLQ
FDPNCKVYSIKCRFKYTFAKMECDPIYAAYQRLYEAPGKLALKDFFYSIS
KPAVEYVGLGKLPSESDYLVAYDQEWEACLHNLIRECILHNSTTESDVYV
LTDPQDTRGQISIKARFKANLFVNVRHSYFYQVLLQSSIVEEYIGSPKYY
IATGFFRKRGYQDPVNCTIGGDALDPHVEIPTLLIVTPVYFPRGAKHRLL
HQAANFWSRSAKDTFPYIKWDFSYLSAN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5hsw KSHV SOX mediated host shutoff: the molecular mechanism underlying mRNA transcript processing.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		F179 K246 C247 R248 F249 Y373
Binding residue
(residue number reindexed from 1)		F145 K211 C212 R213 F214 Y329
Binding affinityPDBbind-CN: Kd=48.9uM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:5hsw, PDBe:5hsw, PDBj:5hsw
PDBsum5hsw
PubMed28132029
UniProtP88925

[Back to BioLiP]