Structure of PDB 5hru Chain A Binding Site BS01

Receptor Information
>5hru Chain A (length=305) Species: 5855 (Plasmodium vivax) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPKIVLVGSGMIGGVMATLIVQKNLGDVVMFDVVKNMPQGKALDTSHSNV
MAYSNCKVTGSNSYDDLKGADVVIVTAGFTKAPRDDLLPLNNKIMIEIGG
HIKNLCPNAFIIVVTNPVDVMVQLLFEHSGVPKNKIIGLGGVLDTSRLKY
YISQKLNVCPRDVNALIVGAHGNKMVLLKRYITVGGIPLQEFINNKKITD
EEVEGIFDRTVNTALEIVNLLASPYVAPAAAIIEMAESYLKDIKKVLVCS
TLLEGQYGHSNIFGGTPLVIGGTGVEQVIELQLNAEEKTKFDEAVAETKR
MKALI
Ligand information
Receptor-Ligand Complex Structure
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PDB5hru Crystal structure of a DNA aptamer bound to PvLDH elucidates novel single-stranded DNA structural elements for folding and recognition
Resolution1.71 Å
Binding residue
(original residue number in PDB)		M14 V36 F82 T83 L232 S234 Y236
Binding residue
(residue number reindexed from 1)		M11 V33 F79 T80 L221 S223 Y225
Enzymatic activity
Catalytic site (original residue number in PDB) R95 D155 R158 H182
Catalytic site (residue number reindexed from 1) R84 D144 R147 H171
Enzyme Commision number 1.1.1.27: L-lactate dehydrogenase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0004459 L-lactate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0006089 lactate metabolic process
GO:0006090 pyruvate metabolic process
GO:0019752 carboxylic acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5hru, PDBe:5hru, PDBj:5hru
PDBsum5hru
PubMed27725738
UniProtQ4PRK9

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