Structure of PDB 5hrt Chain A Binding Site BS01

Receptor Information
>5hrt Chain A (length=786) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TNTSGSCKGRCFELQDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDR
CGEVRNEENACHCSEDCLSRGDCCTNYQVVCKGESHWVDDDCEEIRVPEC
PAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHAPYMRPVYP
TKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGG
QPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERPSVYAFY
SEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLKLHRCVNVIFV
GDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRPKIPNNLKYDPKA
IIANLTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDLHLLVERRWHVARK
PLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGPTFKYRTKVPPFENI
ELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTLPEEVSRPNYPGIM
YLQSDFDLGCTCDSTEERHLLYGRPAVLYRTSYDILYHTDFESGYSEIFL
MPLWTSYTISKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMS
YGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWTYFQRVLVKKYASE
RNGVNVISGPIFDYNYNGLRDIEDEIKQYVEGSSIPVPTHYYSIITSCLD
FTQPADKCDGPLSVSSFILPHRPDNDESCNSSEDESKWVEELMKMHTARV
RDIEHLTGLDFYRKTSRSYSEILTLKTYLHTYESEI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5hrt Structural basis for specific inhibition of Autotaxin by a DNA aptamer
Resolution1.997 Å
Binding residue
(original residue number in PDB)		R244 G245 R246 E247 H315 H452 A454 R455 P457 L458 S465 K467 F469 F470 D473
Binding residue
(residue number reindexed from 1)		R188 G189 R190 E191 H259 H396 A398 R399 P401 L402 S409 K411 F413 F414 D417
Binding affinityPDBbind-CN: Kd=1.3nM
Enzymatic activity
Enzyme Commision number 3.1.4.39: alkylglycerophosphoethanolamine phosphodiesterase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004528 phosphodiesterase I activity
GO:0004551 dinucleotide phosphatase activity
GO:0004622 lysophospholipase activity
GO:0004630 phospholipase D activity
GO:0005044 scavenger receptor activity
GO:0005509 calcium ion binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0030247 polysaccharide binding
GO:0046872 metal ion binding
GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0009395 phospholipid catabolic process
GO:0010634 positive regulation of epithelial cell migration
GO:0016042 lipid catabolic process
GO:0016192 vesicle-mediated transport
GO:0030149 sphingolipid catabolic process
GO:0030334 regulation of cell migration
GO:0034638 phosphatidylcholine catabolic process
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:2000394 positive regulation of lamellipodium morphogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5hrt, PDBe:5hrt, PDBj:5hrt
PDBsum5hrt
PubMed27043297
UniProtQ9R1E6|ENPP2_MOUSE Autotaxin (Gene Name=Enpp2)

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