Structure of PDB 5hp3 Chain A Binding Site BS01

Receptor Information
>5hp3 Chain A (length=394) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLAGVV
MTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRF
LYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDARI
FSPHEPILEEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVL
QGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHL
SRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGD
SAIEVINATTGKDELGRASRLCKHALYCRWMRVHGKVPSHLLRSKITKPN
VYHESKLAAKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSLT
Ligand information
>5hp3 Chain B (length=23) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuccccacauuggacguucaguc
.......................
Receptor-Ligand Complex Structure
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PDB5hp3 Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity.
Resolution3.091 Å
Binding residue
(original residue number in PDB)		V351 T375 K376 H394 E396 C451 R455 H471 N473 R474 S486 G487 E488 G489 C516
Binding residue
(residue number reindexed from 1)		V45 T69 K70 H88 E90 C145 R149 H165 N167 R168 S180 G181 E182 G183 C210
Enzymatic activity
Enzyme Commision number 3.5.4.37: double-stranded RNA adenine deaminase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004000 adenosine deaminase activity
Biological Process
GO:0006396 RNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:5hp3, PDBe:5hp3, PDBj:5hp3
PDBsum5hp3
PubMed27065196
UniProtP78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)

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