Structure of PDB 5hp0 Chain A Binding Site BS01

Receptor Information
>5hp0 Chain A (length=122) Species: 9606,10090 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKT
NGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQGSGSGSQA
MDDLMLSPDDIEQWFTEDPGPD
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5hp0 Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5hp0 Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein.
ResolutionN/A
Binding residue
(original residue number in PDB)		H1782 C1786 C1791 C1796
Binding residue
(residue number reindexed from 1)		H19 C23 C28 C33
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5hp0, PDBe:5hp0, PDBj:5hp0
PDBsum5hp0
PubMed26976603
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53);
P45481|CBP_MOUSE Histone lysine acetyltransferase CREBBP (Gene Name=Crebbp)

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